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NF023 hexasodium

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NF023 hexasodium

Catalog No. TP2272Cas No. 104869-31-0

NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.

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Pack Size	Price	Availability	Quantity
10 mg	$448	35 days
25 mg	$984	35 days

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Product Introduction

Bioactivity

Description	NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.
In vitro	NF023 demonstrates selectivity for recombinant Gi alpha-1 and recombinant Go alpha, with an EC50 value around 300 nM. It inhibits P2X1 receptors independent of voltage changes. At concentrations of 5 and 30 μM, NF023 induces a rightward shift in the concentration-response curve for ATP without altering the maximal response, indicating an inhibitory effect with a KB value of 1.190.2 μM.
In vivo	NF023 (100 µmol/kg i.v.) inhibits the vasopressor responses triggered by α,β-mATP without affecting those induced by noradrenaline in pithed rats[3].
Alias	NF 023, NF 023 hexasodium

Chemical Properties

Molecular Weight	1168.92
Formula	C35H26N4Na6O21S6
Cas No.	104869-31-0

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 105.3mg/mL (90.1mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0086 mL	0.0428 mL	0.0855 mL	0.4277 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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