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NF023 hexasodium
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Catalog No. TP2272Cas No. 104869-31-0
Alias NF 023 hexasodium, NF 023
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist with IC50 values of 0.21 μM, 28.9 μM, > 50 μM, and > 100 μM for human [P2X1], [P2X3], [P2X2], and [P2X4]-mediated responses, respectively.
NF023 hexasodium
😃Good
Catalog No. TP2272Alias NF 023 hexasodium, NF 023Cas No. 104869-31-0
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist with IC50 values of 0.21 μM, 28.9 μM, > 50 μM, and > 100 μM for human [P2X1], [P2X3], [P2X2], and [P2X4]-mediated responses, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $448 | 35 days | |
| 25 mg | $984 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NF023 hexasodium is a selective and competitive P2X1 receptor antagonist with IC50 values of 0.21 μM, 28.9 μM, > 50 μM, and > 100 μM for human [P2X1], [P2X3], [P2X2], and [P2X4]-mediated responses, respectively. |
| In vitro | NF023 demonstrates selectivity for recombinant Gi alpha-1 and recombinant Go alpha, with an EC50 value around 300 nM. It inhibits P2X1 receptors independent of voltage changes. At concentrations of 5 and 30 μM, NF023 induces a rightward shift in the concentration-response curve for ATP without altering the maximal response, indicating an inhibitory effect with a KB value of 1.190.2 μM. |
| In vivo | NF023 (100 µmol/kg i.v.) inhibits vasopressor responses triggered by α,β-mATP without affecting those induced by noradrenaline in pithed rats [3]. |
| Alias | NF 023 hexasodium, NF 023 |
| Molecular Weight | 1168.92 |
| Formula | C35H26N4Na6O21S6 |
| Cas No. | 104869-31-0 |
| Smiles | O=C(NC1=CC=CC(C(NC2=C3C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC3=C(S(=O)(O)=O)C=C2)=O)=C1)NC4=CC=CC(C(NC5=C6C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC6=C(S(=O)(O)=O)C=C5)=O)=C4.[Na].[Na].[Na].[Na].[Na].[Na] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 105.3 mg/mL (90.1 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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