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NP-1815-PX
🥰Excellent
Catalog No. T71155Cas No. 1239578-80-3
NP-1815-PX is a selective P2X4 receptor antagonist with anti-inflammatory and analgesic properties. It inhibits guinea pig tracheal/bronchial smooth muscle contraction and can be used to study chronic pain.
NP-1815-PX
🥰Excellent
Purity: 97.82%
Catalog No. T71155Cas No. 1239578-80-3
NP-1815-PX is a selective P2X4 receptor antagonist with anti-inflammatory and analgesic properties. It inhibits guinea pig tracheal/bronchial smooth muscle contraction and can be used to study chronic pain.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock |
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Purity:97.82%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NP-1815-PX is a selective P2X4 receptor antagonist with anti-inflammatory and analgesic properties. It inhibits guinea pig tracheal/bronchial smooth muscle contraction and can be used to study chronic pain. |
| Targets&IC50 | P2X4R (human):0.26 μM |
| In vitro | NP-1815-PX is a novel selective antagonist of P2X4R. NP-1815-PX effectively inhibited the increase of [Ca2+]i in P2x4R-mediated HP2x4R-1321N1 cells in a concentration-dependent manner, with IC50 value of 0.26 μM for hP2X4R. [1] |
| In vivo | In a mouse model of chronic pain, NP-1815-PX inhibited mechanical abnormal pain induced by nerve damage without any change in basal pain sensitivity or motor function. NP-1815-PX showed inhibitory effect on mechanical abnormal pain in a herpes pain model. [1] |
| Molecular Weight | 424.41 |
| Formula | C21H13N4NaO3S |
| Cas No. | 1239578-80-3 |
| Smiles | O=C1NC2=C(N(C(C1)=O)C3=CC=CC(C4=NOC([N-]4)=S)=C3)C=CC5=C2C=CC=C5.[Na+] |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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