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NPD-2975
NPD-2975
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NPD-2975
Catalog No. T79568
NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic stability and low toxicity potential in human MRC-5 lung fibroblasts, as well as in an acute mouse model of T. b. brucei infection. It inhibits T. b. brucei with an in vitro IC50 of 70 nM and yields IC50 values of 0.16 μM and 0.42 μM against CYP1A2 and CYP2C19 enzymes, respectively [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $143 | 35 days | |
| 5 mg | $668 | 35 days | |
| 10 mg | $1,260 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic stability and low toxicity potential in human MRC-5 lung fibroblasts, as well as in an acute mouse model of T. b. brucei infection. It inhibits T. b. brucei with an in vitro IC50 of 70 nM and yields IC50 values of 0.16 μM and 0.42 μM against CYP1A2 and CYP2C19 enzymes, respectively [1]. |
| In vivo | NPD-2975 administered orally (25 mg/kg, twice daily for five consecutive days; gavage) enhanced survival rates during the initial phase in a murine model of HAT infection [1]. Pharmacokinetic analysis of NPD-2975 in mice [1] revealed the following parameters for the oral (PO) and intraperitoneal (IP) routes: PO—Dose: 50 mg/kg, T_max: 1 h, C_max: 5.25 μM, T_1/2: 3.46 h, AUC_0-6 h: 6064.75 ng·h/mL, Cl: 58.5 mL/min; IP—Dose: 10 mg/kg, T_max: 13.18 h, C_max: 1.06 μM, T_1/2: 3928.37 h, AUC_0-6 h: 171 ng·h/mL. |
| Molecular Weight | 272.28 |
| Formula | C14H13FN4O |
| Cas No. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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