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nSMase2-IN-1
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Catalog No. T79321
nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with an IC50 value of 0.13 ± 0.06 μM, demonstrating metabolic stability in liver microsomes and a favorable brain-to-plasma ratio, indicating effective oral bioavailability. This compound is utilized in nervous system disease research [1].
nSMase2-IN-1
nSMase2-IN-1
😃Good
Catalog No. T79321
nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with an IC50 value of 0.13 ± 0.06 μM, demonstrating metabolic stability in liver microsomes and a favorable brain-to-plasma ratio, indicating effective oral bioavailability. This compound is utilized in nervous system disease research [1].
| Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with an IC50 value of 0.13 ± 0.06 μM, demonstrating metabolic stability in liver microsomes and a favorable brain-to-plasma ratio, indicating effective oral bioavailability. This compound is utilized in nervous system disease research [1]. |
| In vitro | Compound 11j (nSMase2-IN-1) at a concentration of 5μM has demonstrated good metabolic stability in rat liver microsomes, with 95% remaining after a 60-minute incubation period [1]. |
| In vivo | nSMase2-IN-1 (Compound 11j), administered orally at a dose of 10 mg/kg and samples taken for analysis 30 minutes and 2 hours post-dosing, demonstrated efficacy and brain penetration in male Wistar rats [1]. |
| Molecular Weight | 247.3 |
| Formula | C12H17N5O |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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