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Ononetin
🥰Excellent
Catalog No. T23107Cas No. 487-49-0
Alias 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).
Ononetin
🥰Excellent
Purity: 98.15%
Catalog No. T23107Alias 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenoneCas No. 487-49-0
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $47 | In Stock | |
| 10 mg | $72 | In Stock | |
| 25 mg | $139 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $297 | In Stock | |
| 200 mg | $455 | In Stock | |
| 500 mg | $736 | In Stock |
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Purity:98.15%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). |
| Targets&IC50 | TRPM3:0.3 μM |
| In vitro | Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones[1]. |
| In vivo | Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms[2]. |
| Alias | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone |
| Molecular Weight | 258.27 |
| Formula | C15H14O4 |
| Cas No. | 487-49-0 |
| Smiles | COC1=CC=C(CC(=O)C2=C(O)C=C(O)C=C2)C=C1 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (212.96 mM)  Ethanol: < 30 mg/mL (116.16 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Related Tags: buy Ononetin | purchase Ononetin | Ononetin cost | order Ononetin | Ononetin chemical structure | Ononetin in vivo | Ononetin in vitro | Ononetin formula | Ononetin molecular weight
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