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Oxidized ATP trisodium salt
Oxidized ATP trisodium salt (oATP) is a broad-spectrum P2 receptor inhibitor that irreversibly antagonizes P2X7R activation and inhibits CRP-induced NLRP3 inflammasome activation, making it useful in atherosclerosis research [1] [2].
Catalog No. T78639Cas No. 71997-40-5
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Oxidized ATP trisodium salt
Catalog No. T78639Cas No. 71997-40-5
Oxidized ATP trisodium salt (oATP) is a broad-spectrum P2 receptor inhibitor that irreversibly antagonizes P2X7R activation and inhibits CRP-induced NLRP3 inflammasome activation, making it useful in atherosclerosis research [1] [2].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Oxidized ATP trisodium salt (oATP) is a broad-spectrum P2 receptor inhibitor that irreversibly antagonizes P2X7R activation and inhibits CRP-induced NLRP3 inflammasome activation, making it useful in atherosclerosis research [1] [2]. |
| In vitro | Oxidized ATP trisodium salt at a concentration of 100 μM for 1 hour inhibits the activation of caspase-1 and the maturation of IL-1β induced by CRP at 20 μg/mL for 24 hours in HUVECs [1]. |
| In vivo | Oxidized ATP trisodium salt (300 μg/mouse, i.p., twice a week) mitigates experimentally induced autoimmune uveitis (EAU) in B6 mice [2]. |
| Alias | oATP trisodium salt |
| Molecular Weight | 571.11 |
| Formula | C10H11N5Na3O13P3 |
| Cas No. | 71997-40-5 |
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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