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P505-15 Acetate

🥰Excellent
Catalog No. T24584Cas No. 1370261-98-5
Alias PRT-062607 Acetate, PRT062607 Acetate, PRT 062607 Acetate, P50515 Acetate, P505 15 Acetate

P505-15 Acetate is a selective inhibitor of spleen tyrosine kinase that acts by suppressing leukocyte immune function and inflammation and leading to a reduction in arthritis score and attenuated histological damage.

P505-15 Acetate

P505-15 Acetate

🥰Excellent
Purity: 99.28%
Catalog No. T24584Alias PRT-062607 Acetate, PRT062607 Acetate, PRT 062607 Acetate, P50515 Acetate, P505 15 AcetateCas No. 1370261-98-5
P505-15 Acetate is a selective inhibitor of spleen tyrosine kinase that acts by suppressing leukocyte immune function and inflammation and leading to a reduction in arthritis score and attenuated histological damage.
Pack SizePriceAvailabilityQuantity
1 mg$54In Stock
5 mg$127In Stock
10 mg$196In Stock
25 mg$347In Stock
50 mg$523In Stock
100 mg$793In Stock
500 mg$1,630In Stock
1 mL x 10 mM (in DMSO)$227In Stock
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Purity:99.28%
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Product Introduction

Bioactivity
Description
P505-15 Acetate is a selective inhibitor of spleen tyrosine kinase that acts by suppressing leukocyte immune function and inflammation and leading to a reduction in arthritis score and attenuated histological damage.
Targets&IC50
Syk kinase:1-2 nM
In vitro
In human whole blood, P505-15 potently inhibited B cell antigen receptor-mediated B cell signaling and activation (IC50 0.27 and 0.28 μM, respectively) and Fcε receptor 1-mediated basophil degranulation (IC50 0.15 μM) [1]. P505-15 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL [2]. PRT318 and P505-15 effectively antagonize CLL cell survival after BCR triggering and in nurse-like cell-co-cultures. Moreover, they inhibit BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. PRT318 and P505-15 furthermore inhibit Syk and extracellular signal-regulated kinase phosphorylation after BCR triggering [3].
In vivo
Similar levels of ex vivo inhibition were measured after dosing in mice (Syk signaling IC50 0.32 μM). Oral administration of P505-15 produced dose-dependent anti-inflammatory activity in two rodent models of rheumatoid arthritis [1]. Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with P505-15 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations [2].
AliasPRT-062607 Acetate, PRT062607 Acetate, PRT 062607 Acetate, P50515 Acetate, P505 15 Acetate
Chemical Properties
Molecular Weight453.5
FormulaC21H27N9O3
Cas No.1370261-98-5
SmilesCC(O)=O.N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (22.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2051 mL11.0254 mL22.0507 mL110.2536 mL
5 mM0.4410 mL2.2051 mL4.4101 mL22.0507 mL
10 mM0.2205 mL1.1025 mL2.2051 mL11.0254 mL
20 mM0.1103 mL0.5513 mL1.1025 mL5.5127 mL

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