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PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. This compound is utilized in cancer research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $117 | In Stock | |
5 mg | $268 | In Stock | |
10 mg | $395 | In Stock | |
25 mg | $592 | In Stock | |
50 mg | $828 | In Stock | |
100 mg | $1,130 | In Stock | |
500 mg | $2,270 | In Stock | |
1 mL x 10 mM (in DMSO) | $258 | In Stock |
Description | PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. This compound is utilized in cancer research. |
In vitro | PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibits the growth of a PBRM1-dependent prostate cancer cell line. It exhibits binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B, and SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM, and 69 μM, respectively, and inhibits PBRM1-BD2 with an IC50 of 1.0 μM[1]. |
Molecular Weight | 311.14 |
Formula | C14H9Cl2FN2O |
Cas No. | 2819989-57-4 |
Smiles | O=C1C=2C(NC(N1)C3=C(Cl)C=CC=C3F)=CC=CC2Cl |
Relative Density. | 1.433 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (144.63 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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