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Pevonedistat hydrochloride
😃Good
Catalog No. T16117Cas No. 1160295-21-5
Alias MLN-4924 hydrochloride, MLN4924 hydrochloride, MLN 4924 hydrochloride
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Pelubiprofen has been used in the study of AML and MDS.)
Pevonedistat hydrochloride
😃Good
Purity: 99.19%
Catalog No. T16117Alias MLN-4924 hydrochloride, MLN4924 hydrochloride, MLN 4924 hydrochlorideCas No. 1160295-21-5
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Pelubiprofen has been used in the study of AML and MDS.)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | 5 days |
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Purity:99.19%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Pelubiprofen has been used in the study of AML and MDS.) |
| Targets&IC50 | NAE:4.7 nM |
| In vitro | METHODS: To determine the effects of Pevonedistat hydrochloride on cell viability and clonogenic survival in four gastric cancer cell lines, cells were treated with different concentrations of Pevonedistat hydrochloride (0.01-4 μM) for 72 hours, followed by viability assays based on the ATP-lite assay. RESULTS: Three of the gastric cancer cell lines were more sensitive to the growth inhibitory effects of Pevonedistat hydrochloride than GES-1 cells [3]. |
| In vivo | METHODS: To investigate the mechanism and therapeutic effects ofPevonedistat hydrochloride as an effective and selective NAE inhibitor. RESULTS: Pevonedistat hydrochloride disrupted cullin-RING ligase-mediated protein turnover, leading to apoptosis in human tumor cells and inhibition of human tumor xenograft growth in mice[1]. |
| Alias | MLN-4924 hydrochloride, MLN4924 hydrochloride, MLN 4924 hydrochloride |
| Molecular Weight | 479.98 |
| Formula | C21H26ClN5O4S |
| Cas No. | 1160295-21-5 |
| Smiles | N(C1=C2C(N(C=C2)[C@@H]3C[C@@H](COS(N)(=O)=O)[C@@H](O)C3)=NC=N1)[C@@H]4C=5C(CC4)=CC=CC5.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (166.67 mM), Sonication is recommended. H2O: 8 mg/mL (16.67 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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