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PF-9184

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Purity:97.64%

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COA HPLC LCMS HNMR

PF-9184

Catalog No. T21738Cas No. 1221971-47-6

PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro.

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Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$69	In Stock
10 mg	$105	In Stock
25 mg	Inquiry	In Stock
50 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro.
In vitro	PF-9184 (0.015-100 μM; 24 hours) inhibits IL-1β-stimulated prostaglandin E2 (PGE2) synthesis in rheumatoid arthritis (RASF) in synovial fibroblasts derived from patients and has no apparent cytotoxic effects. PF-9184 (0.015-100 μM) potently blocks mPGES-1 ability to synthesize PGE2 from PGH2, and with no apparent inhibitory effects on COX-2 and prostacyclin synthase in cells. PF-9184 (0.015-100 μM) inhibits PGE2 weakly but has no effect on TXB2 synthesis except at 100 μM in human whole blood and modified blood assays. PF-9184 is a poor inhibitor of recombinant rat mPGES-1 (IC50=1080±398 nM)[1].
In vivo	PF-9184 (oral administration or even local delivery) has no effect on PGE2 synthesis in recombinant rats[1].

Chemical Properties

Molecular Weight	461.32
Formula	C21H14Cl2N2O4S
Cas No.	1221971-47-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (130.06 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1677 mL	10.8385 mL	21.6769 mL	108.3846 mL
5 mM	0.4335 mL	2.1677 mL	4.3354 mL	21.6769 mL
10 mM	0.2168 mL	1.0838 mL	2.1677 mL	10.8385 mL
20 mM	0.1084 mL	0.5419 mL	1.0838 mL	5.4192 mL
50 mM	0.0434 mL	0.2168 mL	0.4335 mL	2.1677 mL
100 mM	0.0217 mL	0.1084 mL	0.2168 mL	1.0838 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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