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Philanthotoxin 74 dihydrochloride

Catalog No. T16524Cas No. 1227301-51-0
Alias PhTx-74 HCl, PhTx 74 dihydrochloride

Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.

Philanthotoxin 74 dihydrochloride

Philanthotoxin 74 dihydrochloride

Purity: 98.6%
Catalog No. T16524Alias PhTx-74 HCl, PhTx 74 dihydrochlorideCas No. 1227301-51-0
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
Pack SizePriceAvailabilityQuantity
1 mg$47In Stock
5 mg$149In Stock
50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$199In Stock
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Purity:98.6%
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Product Introduction

Bioactivity
Description
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
Targets&IC50
GluR1:296 nM
In vitro
Philanthotoxin 74 dihydrochloride inhibits the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3 in the micromolar concentration range, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 dihydrochloride (500 μM) fully inhibits GluA1/A2R receptors and produces 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74 dihydrochloride (100 and 500 μM) displays a pronounced channel block (> 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Philanthotoxin 74 dihydrochloride inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2[1].
AliasPhTx-74 HCl, PhTx 74 dihydrochloride
Chemical Properties
Molecular Weight507.54
FormulaC24H44Cl2N4O3
Cas No.1227301-51-0
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (177.33 mM), Sonication is recommended.
H2O: 40 mg/mL (78.81 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.9703 mL9.8514 mL19.7029 mL98.5144 mL
5 mM0.3941 mL1.9703 mL3.9406 mL19.7029 mL
10 mM0.1970 mL0.9851 mL1.9703 mL9.8514 mL
20 mM0.0985 mL0.4926 mL0.9851 mL4.9257 mL
50 mM0.0394 mL0.1970 mL0.3941 mL1.9703 mL
DMSO
1mg5mg10mg50mg
100 mM0.0197 mL0.0985 mL0.1970 mL0.9851 mL

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