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Philanthotoxin 74 dihydrochloride

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Purity:98.6%

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COA HPLC HNMR

Philanthotoxin 74 dihydrochloride

Catalog No. T16524Cas No. 1227301-51-0

Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.

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Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$149	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$199	In Stock

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Product Introduction

Bioactivity

Description	Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
In vitro	Philanthotoxin 74 dihydrochloride inhibits the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3 in the micromolar concentration range, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 dihydrochloride (500 μM) fully inhibits GluA1/A2R receptors and produces 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74 dihydrochloride (100 and 500 μM) displays a pronounced channel block (> 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Philanthotoxin 74 dihydrochloride inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2[1].
Alias	PhTx-74 HCl, PhTx 74 dihydrochloride

Chemical Properties

Molecular Weight	507.54
Formula	C24H44Cl2N4O3
Cas No.	1227301-51-0

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (177.33 mM)

H2O: 40 mg/mL (78.81 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9703 mL	9.8514 mL	19.7029 mL	98.5144 mL
5 mM	0.3941 mL	1.9703 mL	3.9406 mL	19.7029 mL
10 mM	0.1970 mL	0.9851 mL	1.9703 mL	9.8514 mL
20 mM	0.0985 mL	0.4926 mL	0.9851 mL	4.9257 mL
50 mM	0.0394 mL	0.1970 mL	0.3941 mL	1.9703 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.9851 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc