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PI3K/AKT-IN-1
🥰Excellent
Catalog No. T62997Cas No. 3033069-84-7
PI3K/AKT-IN-1 is a dual PI3K and AKT inhibitor with anti-cancer activity. It inhibits PI3Kγ, PI3Kδ, and AKT, suppressing the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis, suitable for cancer research.
PI3K/AKT-IN-1
🥰Excellent
Catalog No. T62997Cas No. 3033069-84-7
PI3K/AKT-IN-1 is a dual PI3K and AKT inhibitor with anti-cancer activity. It inhibits PI3Kγ, PI3Kδ, and AKT, suppressing the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis, suitable for cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $71 | In Stock | |
| 5 mg | $172 | In Stock | |
| 10 mg | $242 | In Stock | |
| 25 mg | $416 | In Stock | |
| 50 mg | $565 | In Stock | |
| 100 mg | $826 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $167 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PI3K/AKT-IN-1 is a dual PI3K and AKT inhibitor with anti-cancer activity. It inhibits PI3Kγ, PI3Kδ, and AKT, suppressing the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis, suitable for cancer research. |
| Targets&IC50 | PI3Kγ:6.99 μM, PI3Kδ:4.01 μM, Akt:3.36 μM |
| In vitro | PI3K/AKT-IN-1 showed excellent cytotoxic activity in breast cancer MCF-7 and leukemia K562 cell lines with IC50 values of 3.22 μM and 2.62 μM, respectively. PI3K/AKT-IN-1 causes the cell cycle to stall in the S phase, leading to apoptosis induced by caspase 3 activation of leukemia (k562) cells. [1] |
| In vivo | The median lethal dose (LD50) of PI3K/AKT-IN-1 was greater than the test dose of 2000 mg/kg, indicating that PI3K/ AKt-in-1 was non-toxic and well tolerated by experimental animals. [1] |
| Molecular Weight | 465.53 |
| Formula | C23H23N5O4S |
| Cas No. | 3033069-84-7 |
| Smiles | N#CC=1C(=NC(=NC1C=2C=CC(OC)=CC2)SC)NN=CC3=CC(OC)=C(OC)C(OC)=C3 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (85.92 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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