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POV-PC
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Catalog No. T35580Cas No. 121324-31-0
Alias POVPC
POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces apoptosis under low serum conditions. POVPC reduces NO production and expression of CD31 and endothelial NOS, triggering ferroptosis in vascular smooth muscle cells, promoting vascular calcification.
POV-PC
😃Good
Catalog No. T35580Alias POVPCCas No. 121324-31-0
POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces apoptosis under low serum conditions. POVPC reduces NO production and expression of CD31 and endothelial NOS, triggering ferroptosis in vascular smooth muscle cells, promoting vascular calcification.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $235 | In Stock | |
| 5 mg | $987 | 35 days | |
| 10 mg | $1,840 | 35 days | |
| 25 mg | $3,950 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces apoptosis under low serum conditions. POVPC reduces NO production and expression of CD31 and endothelial NOS, triggering ferroptosis in vascular smooth muscle cells, promoting vascular calcification. |
| In vitro | POV-PC (0-100 µM; 13 h) Inhibited VSMC growth in a dose-dependent manner. POV-PC (50 µM; 2, 4, 6 h) induced apoptosis in a time-dependent manner. [1] POV-PC (30 μg/ml) enhanced endothelial barrier breakdown caused by heat-inactivated Staphylococcus aureus (HKSA). [2] |
| In vivo | In a mouse model of acute lung injury induced by intranasal injection of HKSA, intravenous injection of POV-PC(10 mg/kg) increased HKSA-induced BAL protein content and cell count, as well as tissue expression of TNF-α, KC, IL1β and CCL2. And promoted blood vessel leakage in Evans Blue's lung infiltration monitoring. [2] |
| Alias | POVPC |
| Molecular Weight | 593.73 |
| Formula | C29H56NO9P |
| Cas No. | 121324-31-0 |
| Smiles | [C@H](COP(OCC[N+](C)(C)C)(=O)[O-])(COC(CCCCCCCCCCCCCCC)=O)OC(CCCC=O)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (13.47 mM), Sonication is recommended. DMF: 8 mg/mL (13.47 mM), Sonication is recommended. Ethanol: 8 mg/mL (13.47 mM), Sonication is recommended. PBS (pH 7.2): 8 mg/mL (13.47 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/DMF/Ethanol/PBS (pH 7.2)
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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