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Prednisolone

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Catalog No. T1560Cas No. 50-24-8
Alias Predonine, Metacortandralone, Hydroretrocortine

Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Prednisolone

Prednisolone

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Purity: 99.85%
Catalog No. T1560Alias Predonine, Metacortandralone, HydroretrocortineCas No. 50-24-8
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Pack SizePriceAvailabilityQuantity
50 mg$29In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:99.85%
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Product Introduction

Bioactivity
Description
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
In vitro
In guinea pigs, Prednisolone significantly reduces the partial pressure of oxygen in the pleural lining (PL-oxygen tension). In rats, Prednisolone (5 mg/kg) induces diaphragm contraction and histological alterations, resulting in an increased number of diaphragm bundles.
In vivo
In quadriceps and soleus muscles, Prednisolone (0.75 mg/kg) is effective in reducing the populations of macrophages, CD4(+) T cells, CD8+ T cells, and eosinophils. At a dosage of 50 mg/kg, Prednisolone suppresses the levels of mRNA for NOS stimulated by lipopolysaccharides in neutrophils of mice. Furthermore, Prednisolone mediates its anti-inflammatory effects by decreasing the expression of cell adhesion molecules.
AliasPredonine, Metacortandralone, Hydroretrocortine
Chemical Properties
Molecular Weight360.44
FormulaC21H28O5
Cas No.50-24-8
SmilesCC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO
Relative Density.1.0963 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 10 mg/mL (27.74 mM)
DMSO: 45 mg/mL (124.85 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.7744 mL13.8719 mL27.7439 mL138.7193 mL
5 mM0.5549 mL2.7744 mL5.5488 mL27.7439 mL
10 mM0.2774 mL1.3872 mL2.7744 mL13.8719 mL
20 mM0.1387 mL0.6936 mL1.3872 mL6.9360 mL
DMSO
1mg5mg10mg50mg
50 mM0.0555 mL0.2774 mL0.5549 mL2.7744 mL
100 mM0.0277 mL0.1387 mL0.2774 mL1.3872 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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