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PROTAC Bcl2 degrader-1
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Catalog No. T10485Cas No. 2378801-85-3
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
PROTAC Bcl2 degrader-1
😃Good
Catalog No. T10485Cas No. 2378801-85-3
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $456 | Backorder | |
| 5 mg | $813 | Backorder | |
| 10 mg | $1,240 | Backorder | |
| 50 mg | Inquiry | Backorder | |
| 100 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM). |
| Targets&IC50 | BCL2:3 μM (DC50), BCL2:4.94 μM, MCL1:11.81 μM |
| Molecular Weight | 941.84 |
| Formula | C45H45BrN6O10S |
| Cas No. | 2378801-85-3 |
| Relative Density. | 1.54 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (26.54 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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