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PU139
Catalog No. T28471Cas No. 158093-65-3
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $56 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $213 | In Stock | |
| 25 mg | $463 | In Stock | |
| 50 mg | $668 | In Stock | |
| 100 mg | $932 | In Stock | |
| 500 mg | $1,860 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PU139 is a novel inhibitor of histone acetyltransferase (HAT). |
| Targets&IC50 | GCN5:8.39 μM (IC50), CBP:2.49 μM (IC50), p300:5.35 μM (IC50), PCAF:9.74 μM (IC50) |
| In vitro | PU139 inhibits cell growth with GI50s of <60 μM (A431, A549, A2780, HCT116, HepG2, SW480, U-87 MG and SK-N-SH and MCF7 cells). PU139 (0-100 μM; 24-72 hours) triggers caspase-independent cell death in the neuroblastoma cell line SK-N-SH[1]. |
| In vivo | PU139 (25 mg/kg; i.p.) enhances the growth-inhibitory effects of the chemotherapeutic agent Doxorubicin. |
| Alias | PU 139, PU-139 |
| Molecular Weight | 246.26 |
| Formula | C12H7FN2OS |
| Cas No. | 158093-65-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/ml, Sonication is recommended.  |
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