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Purpurogallin

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Purity:98.23%

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COA HNMR HPLC

Purpurogallin

Catalog No. T16685Cas No. 569-77-7

Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 μM). Purpurogallin also has antioxidant and anti-inflammatory effects.

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Pack Size	Price	Availability
5 mg	$48	In Stock
10 mg	$82	In Stock
25 mg	$124	In Stock
50 mg	$166	In Stock
100 mg	$249	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock

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Product Introduction

Bioactivity

Description	Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 µM). Purpurogallin also has antioxidant and anti-inflammatory effects.
In vitro	Purpurogallin (100 μM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. Purpurogallin (50 or 100 μM; 7 or 25 hours; BV2 murine microglial cells) treatment decreases the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells[1].
In vivo	By the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression, Purpurogallin (100-400?μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect [2].

Chemical Properties

Molecular Weight	220.18
Formula	C11H8O5
Cas No.	569-77-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (567.72 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5417 mL	22.7087 mL	45.4174 mL	227.0869 mL
5 mM	0.9083 mL	4.5417 mL	9.0835 mL	45.4174 mL
10 mM	0.4542 mL	2.2709 mL	4.5417 mL	22.7087 mL
20 mM	0.2271 mL	1.1354 mL	2.2709 mL	11.3543 mL
50 mM	0.0908 mL	0.4542 mL	0.9083 mL	4.5417 mL
100 mM	0.0454 mL	0.2271 mL	0.4542 mL	2.2709 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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