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Pyridoxylamine

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Purity:99.25%

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COA HNMR HPLC

Pyridoxylamine

Catalog No. T12588Cas No. 85-87-0

Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).

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Pack Size	Price	Availability
10 mg	$38	In Stock
25 mg	$61	In Stock
50 mg	$89	In Stock
100 mg	$128	In Stock
1 mL x 10 mM (in DMSO)	$147	In Stock

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Product Introduction

Bioactivity

Description	Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).
In vitro	Pyridoxylamine (PM) is a member of the B6 vitamer family,and is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1].
In vivo	In STZ diabetic rats, Pyridoxylamine inhibited the formation of CML and CEL and the cross-linking of skin collagen, ultimately inhibiting the development of nephropathy. Pyridoxamine does not appear to act as an antioxidant because it does not inhibit lipid peroxidation. However, it prevents modification of proteins by lipid peroxidation products, including inhibition of the formation of adducts of malondialdehyde and 4-hydroxynonenal on proteins in Zucker rats [1].
Alias	pyridoxamine

Chemical Properties

Molecular Weight	168.19
Formula	C8H12N2O2
Cas No.	85-87-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (386.47 mM)

H2O: 6.25 mg/mL (37.16 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.9457 mL	29.7283 mL	59.4566 mL	297.2828 mL
5 mM	1.1891 mL	5.9457 mL	11.8913 mL	59.4566 mL
10 mM	0.5946 mL	2.9728 mL	5.9457 mL	29.7283 mL
20 mM	0.2973 mL	1.4864 mL	2.9728 mL	14.8641 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1189 mL	0.5946 mL	1.1891 mL	5.9457 mL
100 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9728 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc