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Pyridoxylamine

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Catalog No. T12588Cas No. 85-87-0
Alias pyridoxamine

Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).

Pyridoxylamine

Pyridoxylamine

🥰Excellent
Purity: 99.25%
Catalog No. T12588Alias pyridoxamineCas No. 85-87-0
Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).
Pack SizePriceAvailabilityQuantity
10 mg$38In Stock
25 mg$61In Stock
50 mg$89In Stock
100 mg$128In Stock
1 mL x 10 mM (in DMSO)$147In Stock
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Purity:99.25%
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Product Introduction

Bioactivity
Description
Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).
In vitro
Pyridoxylamine (PM) is a member of the B6 vitamer family,and is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1].
In vivo
In STZ diabetic rats, Pyridoxylamine inhibited the formation of CML and CEL and the cross-linking of skin collagen, ultimately inhibiting the development of nephropathy. Pyridoxamine does not appear to act as an antioxidant because it does not inhibit lipid peroxidation. However, it prevents modification of proteins by lipid peroxidation products, including inhibition of the formation of adducts of malondialdehyde and 4-hydroxynonenal on proteins in Zucker rats [1].
Aliaspyridoxamine
Chemical Properties
Molecular Weight168.19
FormulaC8H12N2O2
Cas No.85-87-0
SmilesC(N)C=1C(CO)=CN=C(C)C1O
Relative Density.1.282g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/mL (386.47 mM), Sonication is recommended.
H2O: 6.25 mg/mL (37.16 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM5.9457 mL29.7283 mL59.4566 mL297.2828 mL
5 mM1.1891 mL5.9457 mL11.8913 mL59.4566 mL
10 mM0.5946 mL2.9728 mL5.9457 mL29.7283 mL
20 mM0.2973 mL1.4864 mL2.9728 mL14.8641 mL
DMSO
1mg5mg10mg50mg
50 mM0.1189 mL0.5946 mL1.1891 mL5.9457 mL
100 mM0.0595 mL0.2973 mL0.5946 mL2.9728 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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