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Quassin
😃Good
Catalog No. TN2120Cas No. 76-78-8
Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.
Quassin
😃Good
Catalog No. TN2120Cas No. 76-78-8
Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $213 | 35 days | |
| 5 mg | $795 | 35 days | |
| 10 mg | $1,160 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion. |
| Targets&IC50 | P. falciparum:0.15 μM (IC50) |
| In vitro | An HPLC method was employed for purification of the biologically active Quassinoids; Quassin (Q) and neo-Quassin (NQ), further characterized by MALDI-TOF analyses. Purified Q, NQ and the crude bark extract (S1) along with artesunate (AS) were studied for their in vitro anti-plasmodial activity. The in vivo toxicity studies at intraperitoneal doses with higher concentrations of the crude bark extract (S1) in Balb/C mice ruled out the apprehension of toxicity. Interaction studies between the test compounds among themselves (Q+NQ) and individually with artesunate (AS+Q, AS+NQ), were carried out in vitro at four ratios (1:5, 1:2, 2:1 and 5:1) on chloroquine sensitive (MRC-pf-20) and resistant (MRC-pf-303) strains of Plasmodium falciparum. The crude bark extracts of Q. amara exhibited higher P. falciparum inhibitory activity (IC(50)=0.0025 microg/ml) as compared to that of the isolated compounds, Quassin (IC(50)=0.06 microg/ml, 0.15 microM), neo-Quassin (IC(50)=0.04 microg/ml, 0.1 microM) and also to the positive control, artesunate (IC(50)=0.02 microg/ml, 0.05 microM)[1] |
| Molecular Weight | 388.45 |
| Formula | C22H28O6 |
| Cas No. | 76-78-8 |
| Relative Density. | 1.23 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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