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Risdiplam
🥰Excellent
Catalog No. T16757Cas No. 1825352-65-5
Alias RO7034067, RG7916
Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.
Risdiplam
🥰Excellent
Purity: 99.43%
Catalog No. T16757Alias RO7034067, RG7916Cas No. 1825352-65-5
Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 52 € | In Stock | |
| 2 mg | 76 € | In Stock | |
| 5 mg | 122 € | In Stock | |
| 10 mg | 200 € | In Stock | |
| 25 mg | 357 € | In Stock | |
| 50 mg | 531 € | In Stock | |
| 100 mg | 746 € | In Stock |
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Purity:99.43%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels. |
| In vitro | METHODS: LLC-PK1, MDCKII, L-MDR1 (LLC-PK1 cells transfected with human MDR1), L-Mdr1a (LLC-PK1 cells transfected with rodent Mdr1a), M-BCRP (MDCKII cells transfected with human breast cancer resistance protein; BCRP), and M-Bcrp1 (MDCKII cells transfected with rodent Bcrp1) cells were treated with Risdiplam (RG7916) (1 μM) and 10 μM Lucifer Yellow added to the donor compartment to initiate transcellular transport. RESULTS Risdiplam had a mean passive permeability of approximately 350 nm/s in parental LLC-PK1 cells. Similar permeability was observed in L-MDR1, L-Mdra1, M-BCRP, and M-Bcrp cells in the presence of the inhibitor. [1] |
| In vivo | METHODS: Wistar rats received either a single oral dose of 14C-risdiplam (RO7034067) (by gastric gavage) or a single intravenous dose of 14C-risdiplam (by tail vein injection). Dose levels for oral and intravenous doses were 5 or 2 mg/kg, respectively. RESULTS Radioactive 14C-risdiplam (RO7034067) was rapidly and extensively distributed in rat QWBA after oral administration, with peak concentrations in most tissues measured at 2 hours. Radioactivity concentrations in plasma and tissues declined during the study period. [1] |
| Alias | RO7034067, RG7916 |
| Molecular Weight | 401.46 |
| Formula | C22H23N7O |
| Cas No. | 1825352-65-5 |
| Smiles | Cc1cn2nc(cc(C)c2n1)-c1cc(=O)n2cc(ccc2n1)N1CCNC2(CC2)C1 |
| Relative Density. | 1.50 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: < 1 mg/mL (insoluble）, Sonication is recommended.  Ethanol: 2 mg/mL (4.98 mM), Sonication is recommended. H2O: 2.22 mg/mL (5.53 mM), when pH is adjusted to 6 with HCl. Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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