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RS-1

Catalog No. T6972 CAS 312756-74-4

RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.

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RS-1, CAS 312756-74-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 222.00
100 mg	In stock	$ 372.00
200 mg	In stock	$ 545.00
500 mg	In stock	$ 869.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.

In vitro

RS-1 serves as an activator of RAD51, enhancing the binding affinity of hRAD51 to DNA, with a dissociation constant (Kd) between 48 nM and 107 nM, in conditions containing ATP or ADP and even in the absence of nucleotide cofactors, without inhibiting ATPase activity of RAD51. At a concentration of 20 μM, RS-1 alters the length and helical pitch of hRAD51-DNA complexes. Furthermore, RS-1 progressively augments the strand assimilation activity of hRAD51 across a range of concentrations (0, 1, 5, 10, 15, 20, and 25 μM). At 7.5 μM, it bolsters human cells' resilience to cross-linking agents used in chemotherapy[1]. In addition, RS-1 enhances Cas9-mediated gene editing efficiency in rabbit embryos at concentrations of 0, 7.5, and 15 μM[2].

Molecular Weight	524.23
Formula	C20H16Br2N2O3S
CAS No.	312756-74-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90mg/mL (171.7mM)

References and Literature

1. Jayathilaka K, et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15848-53. 2. Song J, et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016 Jan 28;7:10548.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Bioactive Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RS-1 312756-74-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis RAD51 RS1 inhibit RS 1 Inhibitor CRISPR/Cas9 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.