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RS-1

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Purity:99.72%

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COA HNMR HPLC

RS-1

Catalog No. T6972Cas No. 312756-74-4

RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$72	In Stock
25 mg	$128	In Stock
50 mg	$222	In Stock
100 mg	$372	In Stock
200 mg	$545	In Stock
500 mg	$869	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Product Introduction

Bioactivity

Description

RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.

In vitro

RS-1 serves as an activator of RAD51, enhancing the binding affinity of hRAD51 to DNA, with a dissociation constant (Kd) between 48 nM and 107 nM, in conditions containing ATP or ADP and even in the absence of nucleotide cofactors, without inhibiting ATPase activity of RAD51. At a concentration of 20 μM, RS-1 alters the length and helical pitch of hRAD51-DNA complexes. Furthermore, RS-1 progressively augments the strand assimilation activity of hRAD51 across a range of concentrations (0, 1, 5, 10, 15, 20, and 25 μM). At 7.5 μM, it bolsters human cells' resilience to cross-linking agents used in chemotherapy[1]. In addition, RS-1 enhances Cas9-mediated gene editing efficiency in rabbit embryos at concentrations of 0, 7.5, and 15 μM[2].

Chemical Properties

Molecular Weight	524.23
Formula	C20H16Br2N2O3S
Cas No.	312756-74-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90mg/mL (171.7mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9076 mL	9.5378 mL	19.0756 mL	95.3780 mL
5 mM	0.3815 mL	1.9076 mL	3.8151 mL	19.0756 mL
10 mM	0.1908 mL	0.9538 mL	1.9076 mL	9.5378 mL
20 mM	0.0954 mL	0.4769 mL	0.9538 mL	4.7689 mL
50 mM	0.0382 mL	0.1908 mL	0.3815 mL	1.9076 mL
100 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.9538 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc