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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $158 | In Stock | |
5 mg | $390 | In Stock | |
10 mg | $590 | In Stock | |
25 mg | $943 | In Stock | |
50 mg | $1,280 | In Stock | |
100 mg | $1,730 | In Stock | |
500 mg | $3,460 | In Stock | |
1 mL x 10 mM (in DMSO) | $459 | In Stock |
Description | Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory properties and can be used in the acute treatment of chronic heart failure. Saterinone inhibited crude cAMP phosphodiesterase (PDE) activity in guinea pig right ventricular homogenates The ic50 value is 2.3 × 10(-5) mol/l. |
Targets&IC50 | Isoenzyme III:0.06 mumol/l, Pig papillary muscles:9.1 mumol/l(EC50) |
In vitro | Saterinone selectively and potently inhibited the isoenzyme III of PDE (IC50 = 0.06 mumol/l). Thus, saterinone proved to be a selective inhibitor of 'low-Km, cAMP specific' PDE III.[1] |
In vivo | Saterinone (1-30 mumol/l) exerted a concentration-dependent positive inotropic effect (EC50 = 9.1 mumol/l) in guinea pig papillary muscles.[1] |
Molecular Weight | 474.55 |
Formula | C27H30N4O4 |
Cas No. | 102669-89-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.75 mg/mL (10 mM) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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