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SB 206553 hydrochloride
🥰Excellent
Catalog No. T23314Cas No. 1197334-04-5
Alias SB206553 hydrochloride
SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research.
SB 206553 hydrochloride
🥰Excellent
Catalog No. T23314Alias SB206553 hydrochlorideCas No. 1197334-04-5
SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $86 | In Stock | |
| 5 mg | $209 | In Stock | |
| 10 mg | $313 | In Stock | |
| 25 mg | $528 | In Stock | |
| 50 mg | $753 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research. |
| In vitro | SB 206553 hydrochloride (50 μM) prevented the promotion of mEPSC induced by the application of α-Me-5HT (10 μM), while the rise and decay time constants of mEPSC administered by α-Me-5HT remained unchanged in the presence of SB 206553 hydrochloride. [1] |
| In vivo | Intraperitoneal administration of SB 206553 hydrochloride (1-10 mg/kg) caused a dose-dependent increase in DA release from the accumbens and striatum in rats. [2] SB 206553 hydrochloride (1-10mg/kg), only 10mg/kg, enhanced c-Fos expression in STN, striatum (except dorsomedial part), NAcc, inner surface nucleus, substantia nigra reticularis (SNr) and densa (SNc), and ventral tegmental area. [3] |
| Alias | SB206553 hydrochloride |
| Molecular Weight | 328.8 |
| Formula | C17H17ClN4O |
| Cas No. | 1197334-04-5 |
| Smiles | Cl.O=C(NC=1C=NC=CC1)N2C3=CC=4C=CN(C4C=C3CC2)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (76.03 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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