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SC57666

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Purity:99.48%

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COA LCMS HPLC FNMR HNMR

SC57666

Catalog No. T12860Cas No. 158959-32-1

SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.

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Pack Size	Price	Availability
1 mg	$197	In Stock
5 mg	$428	In Stock
10 mg	$687	In Stock
25 mg	$1,170	In Stock
50 mg	$1,530	In Stock
100 mg	$1,990	In Stock
1 mL x 10 mM (in DMSO)	$473	In Stock

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Product Introduction

Bioactivity

Description	SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
Targets&IC50	COX-2:26 nM
In vitro	SC57666 exhibits potent inhibition of COX2 (IC50 of 3.2±0.8 nM) in CHO cells stably transfected with human COX isozymes, showing a selectivity of 1000-fold or greater over COX1 (IC50=6000±1900 nM) [1].
In vivo	In the adjuvant-induced arthritis model, SC57666 exhibits oral activity with an ED50 of 1.7 mpk. When administered orally at a dose of 600 mpk, SC57666 does not cause gastric lesions in mice after 5 hours. Similarly, no intestinal damage is observed in rats after 72 hours when administered orally at a dose of 200 mpk [2].

Chemical Properties

Molecular Weight	316.39
Formula	C18H17FO2S
Cas No.	158959-32-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90.0 mg/mL (284.5 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1607 mL	15.8033 mL	31.6066 mL	158.0328 mL
5 mM	0.6321 mL	3.1607 mL	6.3213 mL	31.6066 mL
10 mM	0.3161 mL	1.5803 mL	3.1607 mL	15.8033 mL
20 mM	0.1580 mL	0.7902 mL	1.5803 mL	7.9016 mL
50 mM	0.0632 mL	0.3161 mL	0.6321 mL	3.1607 mL
100 mM	0.0316 mL	0.1580 mL	0.3161 mL	1.5803 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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