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Sennidin B

🥰Excellent
Catalog No. TN1034Cas No. 517-44-2

Sennidin B stimulates glucose incorporation in rat adipocytes.

Sennidin B

Sennidin B

🥰Excellent
Catalog No. TN1034Cas No. 517-44-2
Sennidin B stimulates glucose incorporation in rat adipocytes.
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Product Introduction

Bioactivity
Description
Sennidin B stimulates glucose incorporation in rat adipocytes.
In vitro
The bacterium hydrolyzed sennosides A and Sennidin B to sennidin A and Sennidin B via sennidin A and Sennidin B 8-monoglucosides, respectively. Among nine species of Bifidobacterium having beta-glucosidase activity, only Bifidobacterium dentium and B. adolescentis metabolized sennoside B to Sennidin B, suggesting that the sennoside-metabolizing bacteria produce a novel type of beta-glucosidase capable of hydrolyzing sennosides to sennidins[1]
Chemical Properties
Molecular Weight538.47
FormulaC30H18O10
Cas No.517-44-2
Smiles[H][C@@]1(c2cccc(O)c2C(=O)c2c(O)cc(cc12)C(O)=O)[C@]1([H])c2cccc(O)c2C(=O)c2c(O)cc(cc12)C(O)=O
Relative Density.1.695 g/cm3 at 20℃
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8571 mL9.2856 mL18.5711 mL92.8557 mL
5 mM0.3714 mL1.8571 mL3.7142 mL18.5711 mL
10 mM0.1857 mL0.9286 mL1.8571 mL9.2856 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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