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Sennoside A

Catalog No. T0966Cas No. 81-27-6
Alias NSC 112929

Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.

Sennoside A

Sennoside A

Purity: 99.55%
Catalog No. T0966Alias NSC 112929Cas No. 81-27-6
Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
Pack SizePriceAvailabilityQuantity
20 mg$60In Stock
1 mL x 10 mM (in DMSO)$60In Stock
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Purity:99.55%
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Product Introduction

Bioactivity
Description
Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
Targets&IC50
MAO:17 μM
In vitro
Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine through regulating the spontaneous motility of colon. [2] It mildly inhibits bovine serum monoamine oxidase with IC50 of 17 μM. [1]
In vivo
LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.). [3]
AliasNSC 112929
Chemical Properties
Molecular Weight862.74
FormulaC42H38O20
Cas No.81-27-6
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 95 mg/mL (110.1 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1591 mL5.7955 mL11.5910 mL57.9549 mL
5 mM0.2318 mL1.1591 mL2.3182 mL11.5910 mL
10 mM0.1159 mL0.5795 mL1.1591 mL5.7955 mL
20 mM0.0580 mL0.2898 mL0.5795 mL2.8977 mL
50 mM0.0232 mL0.1159 mL0.2318 mL1.1591 mL
100 mM0.0116 mL0.0580 mL0.1159 mL0.5795 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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