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Seribantumab

🥰Excellent
Catalog No. T76791Cas No. 1334296-12-6
Alias SAR-256212, SAR256212, MM-121, MM121

Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.

Seribantumab

Seribantumab

🥰Excellent
Catalog No. T76791Alias SAR-256212, SAR256212, MM-121, MM121Cas No. 1334296-12-6
Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.
Pack SizePriceAvailabilityQuantity
1 mg$78In Stock
5 mg$237In Stock
10 mg$383In Stock
25 mg$629In Stock
50 mg$889In Stock
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Concentration:9.41 mg/mL
Purity:>95%
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Product Introduction

Bioactivity
Description
Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.
Targets&IC50
LUAD-0061AS3 cell:1.4 μM, MCF-7 cell:45.2 μM, MDA-MB-175-VII cell:0.02 μM, HBECp53 cell:203 μM
In vitro
Methods: seribantumab (0.1, 1, 10 μM) was used to treat cancer cells.
Results: seribantumab inhibited neuregulin (NRG1) fusion dependent tumorigenosis.
The IC50 values of Seribantumab for MDA-MB-175-VII cells, LUAD-0061AS3 cells, MCF-7 cells, and HBECp53 cells were 0.02 μM, 1.4 μM, 45.2 μM, and 203 μM, respectively. [1]
In vivo
Seribantumab (0.6 mg, 0.75 mg, or 1 mg per dose twice weekly) was injected into mice with LUAD-0061AS3 PDX tumors, and results showed that seribantumab was more effective than afatinib in reducing tumor growth. [1]
AliasSAR-256212, SAR256212, MM-121, MM121
Chemical Properties
Molecular Weight143.2 (kDa)
Cas No.1334296-12-6
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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