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SIB-1757

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Purity:98.49%

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COA HNMR HPLC

SIB-1757

Catalog No. T8434Cas No. 31993-01-8

SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)

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Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$89	In Stock
10 mg	$143	In Stock
25 mg	$289	In Stock
50 mg	$455	In Stock
100 mg	$637	In Stock
500 mg	$1,320	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock

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Product Introduction

Bioactivity

Description	SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
In vivo	SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route[1].
Alias	6-methyl-2-[(E)-phenyldiazenyl]pyridin-3

Chemical Properties

Molecular Weight	213.24
Formula	C12H11N3O
Cas No.	31993-01-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.5 mg/mL (25.79 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6896 mL	23.4478 mL	46.8955 mL	234.4776 mL
5 mM	0.9379 mL	4.6896 mL	9.3791 mL	46.8955 mL
10 mM	0.4690 mL	2.3448 mL	4.6896 mL	23.4478 mL
20 mM	0.2345 mL	1.1724 mL	2.3448 mL	11.7239 mL

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