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Skp2 Inhibitor C1

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COA HNMR LCMS

Skp2 Inhibitor C1

Catalog No. T4253Cas No. 432001-69-9

Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.

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Pack Size	Price	Availability
1 mg	$36	In Stock
5 mg	$84	In Stock
10 mg	$137	In Stock
25 mg	$293	In Stock
50 mg	$490	In Stock
100 mg	$715	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock

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Product Introduction

Bioactivity

Description	Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
In vitro	in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels.
Kinase Assay	To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored.
Alias	SKPin C1

Chemical Properties

Molecular Weight	465.34
Formula	C18H13BrN2O4S2
Cas No.	432001-69-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (107.45 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1490 mL	10.7448 mL	21.4897 mL	107.4483 mL
5 mM	0.4298 mL	2.1490 mL	4.2979 mL	21.4897 mL
10 mM	0.2149 mL	1.0745 mL	2.1490 mL	10.7448 mL
20 mM	0.1074 mL	0.5372 mL	1.0745 mL	5.3724 mL
50 mM	0.0430 mL	0.2149 mL	0.4298 mL	2.1490 mL
100 mM	0.0215 mL	0.1074 mL	0.2149 mL	1.0745 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc