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SLC7A11-IN-1
🥰Excellent
Catalog No. T74859Cas No. 3049302-90-8
SLC7A11-IN-1 is an SLC7A11 inhibitor with anti-proliferative and anti-cancer activities. It inhibits cell invasion and metastasis, induces apoptosis and cell cycle arrest. It can be used for research on neurodegenerative diseases.
SLC7A11-IN-1
🥰Excellent
Purity: 95.93%
Catalog No. T74859Cas No. 3049302-90-8
SLC7A11-IN-1 is an SLC7A11 inhibitor with anti-proliferative and anti-cancer activities. It inhibits cell invasion and metastasis, induces apoptosis and cell cycle arrest. It can be used for research on neurodegenerative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $487 | In Stock |
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Purity:95.93%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SLC7A11-IN-1 is an SLC7A11 inhibitor with anti-proliferative and anti-cancer activities. It inhibits cell invasion and metastasis, induces apoptosis and cell cycle arrest. It can be used for research on neurodegenerative diseases. |
| Targets&IC50 | MCF-7 cells:0.18 µM, HCT116 cells:0.03 µM, HepG2 cells:0.17 µM, L02 cells:0.27 µM, MDA-MB-231 cells:0.11 µM |
| In vitro | SLC7A11-IN-1 (compound 2) (0-100 µM; 72 hrs of action) exhibited antiproliferative activity against a variety of cell lines with IC50 values of HCT-116: 0.03 µM, MDA-MB-231: 0.11 µM, MCF-7: 0.18 µM, HepG2: 0.17 µM, LO2: 0.27 µM.[1] SLC7A11-IN-1 (0.5 µM, treated for 24 h) inhibited the invasive and migratory abilities of HCT-116 cells, triggered apoptosis, and arrested the cell cycle in S-phase, as well as significantly reduced intracellular GSH levels, while significantly increasing the expression of reactive oxygen species (ROS). [1] SLC7A11-IN-1 (1 µM, 15 hr treatment) significantly induced DNA damage in HCT-116 cells and upregulated the expression of related proteins. [1] |
| In vivo | SLC7A11-IN-1 (2 mg/kg via tail vein injection every three days for three consecutive times) exhibited tumor growth inhibition in mice. [1] |
| Molecular Weight | 664.35 |
| Formula | C13H17Cl2F3N4O5PtS |
| Cas No. | 3049302-90-8 |
| Smiles | O=C([O-][Pt+4]([Cl-])([Cl-])([OH-])([NH3])[NH3])CCCC(=O)NC1=NC=2C=CC(OC(F)(F)F)=CC2S1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16.00 mg/mL (24.08 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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