Shopping Cart
- Remove All
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $35 | In Stock | |
10 mg | $60 | In Stock | |
25 mg | $123 | In Stock | |
50 mg | $197 | In Stock | |
100 mg | $289 | In Stock | |
500 mg | $698 | In Stock | |
1 mL x 10 mM (in DMSO) | $40 | In Stock |
Description | Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade |
In vitro | Tafamidis binds selectively and with negative cooperativity (K(d)s ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR.?Patient-derived amyloidogenic variants of TTR, including kinetically and thermodynamically less stable mutants, are also stabilized by tafamidis binding[1]. |
Alias | Fx-1006A |
Molecular Weight | 503.33 |
Formula | C21H24Cl2N2O8 |
Cas No. | 951395-08-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 5.03 mg/mL (10 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.