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Tafenoquine (WR 238605) is an antimalarial prophylactic agent with schizonticidal activity, useful in hemolytic anemia research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $81 | In Stock | |
5 mg | $193 | In Stock | |
10 mg | $296 | In Stock | |
25 mg | $525 | In Stock | |
50 mg | $945 | In Stock | |
100 mg | $1,280 | In Stock | |
200 mg | $1,730 | In Stock |
Description | Tafenoquine (WR 238605) is an antimalarial prophylactic agent with schizonticidal activity, useful in hemolytic anemia research. |
In vitro | Methods: Tafenoquine (WR 238605) was treated with macrophage cell line RAW 264.7, and the in vitro toxicity was evaluated using the MTT assay after 24 hours. Results: The IC50 value of Tafenoquine against macrophage cell line RAW 264.7 was 5.9μg/mL.[1] |
In vivo | Methods: Tafenoquine (WR 238605) (3/6mg/kg, oral) was administered to normal C57BL/6 mice (WT) and humanized/CYP 2D6 knock-in mice, and the antimalarial activity of TQ against P. berghei expressing enzymes was evaluated by monitoring luminescence using an in vivo imaging system. Results: Tafenoquine at a dose of 3mg/kg showed no antimalarial activity in CYP 2D knock-out mice; when tested at 6mg/kg, the antimalarial activity of TQ in humanized/CYP 2D6 knock-in mice was partially restored.[1] |
Alias | WR238605, WR 238605 |
Molecular Weight | 463.49 |
Formula | C24H28F3N3O3 |
Cas No. | 106635-80-7 |
Smiles | FC(F)(F)C=1C=CC=C(OC2=C(OC)C=C(NC(C)CCCN)C3=NC(OC)=CC(=C32)C)C1 |
Relative Density. | 1.237 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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