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TEPP-46
Catalog No. T7214Cas No. 1221186-53-3
Alias ML265
TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2) (AC50=92 nM), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity.
TEPP-46
Catalog No. T7214Alias ML265Cas No. 1221186-53-3
TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2) (AC50=92 nM), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $248 | In Stock | |
| 50 mg | $373 | In Stock | |
| 100 mg | $556 | In Stock | |
| 500 mg | $1,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock |
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Purity:98.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2) (AC50=92 nM), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. |
| In vitro | METHODS: Human hepatocellular carcinoma cells, HepG2, were treated with TCEP hydrochloride (100-400 µM) for 3 days, and cell viability was measured by MTT assay. RESULTS: The viability of HepG2 was significantly reduced to 25.68% and 70.92% after treatment with 200 and 400 µM TCEP for 3 days, whereas the lowest concentration of TCEP (100 µM) did not significantly reduce the viability of HepG2 (3.44%). [1] METHODS: Human peripheral blood mononuclear cell PBMCs were treated with TCEP hydrochloride (0.5-1 mM) for 24 h. Morphological and necrotic changes were assessed by Hoechst 33342/PI staining. RESULTS: Necrosis was observed in cells treated with 0.5 mM of TCEP. [2] |
| In vivo | METHODS: To investigate the neurotoxicity and its mechanism in mice, TCEP hydrochloride (10-100 mg/kg) was administered by gavage to Kunming mice once a day for 30 days. RESULTS: Compared with the control group, the water intake of high-dose TCEP group was declined significantly, and the organ index of liver and spleen were increased significantly. In addition, the escape latency of TCEP exposed mice were longer than that in the control group in water maze test, while the total swimming course of high-dose TCEP group was elevated and the swimming time in target quadrant was obviously shortened compared with the control group. TCEP exposure can cause neurotoxicity by increasing thyroid hormones and inducing oxidative damage in mice. [3] |
| Alias | ML265 |
| Molecular Weight | 372.46 |
| Formula | C17H16N4O2S2 |
| Cas No. | 1221186-53-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.42 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.  DMSO: 50 mg/mL (134.24 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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