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Tetrahydrodeoxycorticosterone
🥰Excellent
Catalog No. T37725Cas No. 567-03-3
Alias Tetrahydro-11-deoxycorticosterone, 21-Hydroxypregnanolone
Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.
Tetrahydrodeoxycorticosterone
🥰Excellent
Purity: 99.40%
Catalog No. T37725Alias Tetrahydro-11-deoxycorticosterone, 21-HydroxypregnanoloneCas No. 567-03-3
Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.
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CitedSelect Batch
Purity:99.40%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders. |
| In vitro | At physiological concentrations, the endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) selectively enhances tonic currents mediated by αβδ receptors[1]. In the hippocampus, the reduction of neuronal excitability is observed with 10 nM Tetrahydrodeoxycorticosterone, achieved by augmenting tonic αβδ receptor currents. Notably, in thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, the same effect is not observed with 10 nM Tetrahydrodeoxycorticosterone[1]. |
| In vivo | Sufficient concentrations of Tetrahydrodeoxycorticosterone (THDOC) in the brain tissue of mice with hepatic encephalopathy (HE), arising from toxic liver injury, can induce sedation in animals of the same species[2]. |
| Alias | Tetrahydro-11-deoxycorticosterone, 21-Hydroxypregnanolone |
| Molecular Weight | 334.49 |
| Formula | C21H34O3 |
| Cas No. | 567-03-3 |
| Smiles | [H][C@@]12CC[C@H](C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (269.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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