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Ulocuplumab
🥰Excellent
Catalog No. T76794Cas No. 1375830-34-4
Alias MDX 1338, BMS 936564
Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplumab inhibits the migration of chronic lymphocytic leukemia (CLL) cells under CXCR4 activation, induces apoptosis, and inhibits the growth and migration of cancer cells. Ulocplumab inhibits CXCL12-mediated chronic lymphocytic leukemia (CLL) cell migration in response to CXCR4 activation and induces apoptosis.)
Ulocuplumab
Ulocuplumab
🥰Excellent
Purity: 96.2% (SEC-HPLC)
Catalog No. T76794Alias MDX 1338, BMS 936564Cas No. 1375830-34-4
Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplumab inhibits the migration of chronic lymphocytic leukemia (CLL) cells under CXCR4 activation, induces apoptosis, and inhibits the growth and migration of cancer cells. Ulocplumab inhibits CXCL12-mediated chronic lymphocytic leukemia (CLL) cell migration in response to CXCR4 activation and induces apoptosis.)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $247 | In Stock | |
| 5 mg | $708 | In Stock | |
| 10 mg | $987 | In Stock |
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Concentration:2.29 mg/mL
Purity:96.2% (SEC-HPLC)
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplumab inhibits the migration of chronic lymphocytic leukemia (CLL) cells under CXCR4 activation, induces apoptosis, and inhibits the growth and migration of cancer cells. Ulocplumab inhibits CXCL12-mediated chronic lymphocytic leukemia (CLL) cell migration in response to CXCR4 activation and induces apoptosis.) |
| Targets&IC50 | Ramos cells:10 nM |
| In vitro | Ulocuplumab (0-100 μM; 48 h) lacks antibody-dependent cell-mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) activity. However, it induces CXCR4-binding-mediated apoptosis in Ramos cells and CLL or cancer cell lines. It also demonstrates pro-apoptotic effects in primary leukemia cells from CLL patients [1]. Ulocuplumab (0.2 μM, 2 μM; 15 s) inhibits F-actin polymerization, reduces peak responses to CXCL12, and (20 nM-2 μM; 1 h) additionally inhibits cell migration [1]. At a concentration of 200 nM for 6 hours, Ulocuplumab induces programmed cell death (PCD) independently of caspases [1]. Ulocuplumab (10 μg/mL; 4 h) induces cell death in CLL cells by generating reactive oxygen species (ROS) [1]. Ulocuplumab inhibits CXCL12-induced calcium flux, with an EC50 of 10 nM in Ramos cells [2]. |
| In vivo | Ulocuplumab (3-30 mg/kg; intraperitoneal injection; 5 doses over 3-4 days; a total of 65 days) inhibits tumor growth in a murine multiple myeloma xenograft model, including tumor models with Ramos B cells, HL-60 cells, MOLP-8 cells, Nomo-1 cells, and JJN-3R cells [1]. |
| Alias | MDX 1338, BMS 936564 |
| Molecular Weight | 146.23 kDa |
| Cas No. | 1375830-34-4 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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