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Urocanic acid

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Catalog No. T4759Cas No. 104-98-3
Alias 4-Imidazoleacrylic acid

Urocanic acid (4-Imidazoleacrylic acid), synthesized in the epidermis, functions as a primary absorber of ultraviolet (UV) radiation in mammalian skin.

Urocanic acid

Urocanic acid

🥰Excellent
Purity: 99.84%
Catalog No. T4759Alias 4-Imidazoleacrylic acidCas No. 104-98-3
Urocanic acid (4-Imidazoleacrylic acid), synthesized in the epidermis, functions as a primary absorber of ultraviolet (UV) radiation in mammalian skin.
Pack SizePriceAvailabilityQuantity
1 g$48In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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Purity:99.84%
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Product Introduction

Bioactivity
Description
Urocanic acid (4-Imidazoleacrylic acid), synthesized in the epidermis, functions as a primary absorber of ultraviolet (UV) radiation in mammalian skin.
In vitro
Urocanic acid is produced in the upper epidermal layers through the breakdown of filaggrin— a histidine-rich filament protein generated following the caspase-14-mediated cleavage of profilaggrin—by proteinases into its constituent amino acids[1].
Alias4-Imidazoleacrylic acid
Chemical Properties
Molecular Weight138.12
FormulaC6H6N2O2
Cas No.104-98-3
SmilesOC(=O)\C=C\C1=CNC=N1
Relative Density.1.43g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (72.4 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM7.2401 mL36.2004 mL72.4008 mL362.0041 mL
5 mM1.4480 mL7.2401 mL14.4802 mL72.4008 mL
10 mM0.7240 mL3.6200 mL7.2401 mL36.2004 mL
20 mM0.3620 mL1.8100 mL3.6200 mL18.1002 mL
50 mM0.1448 mL0.7240 mL1.4480 mL7.2401 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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