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cis-Urocanic acid

🥰Excellent
Catalog No. T10824Cas No. 7699-35-6
Alias cis-UCA, (Z)-Urocanic acid, (Z)-Imidazole-4-acrylic acid, (Z)-3-(1H-Imidazol-5-yl)acrylic acid, (E)-Urocanic acid

cis-Urocanic acid ((E)-Urocanic acid) is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.

cis-Urocanic acid

cis-Urocanic acid

🥰Excellent
Purity: 99.78%
Catalog No. T10824Alias cis-UCA, (Z)-Urocanic acid, (Z)-Imidazole-4-acrylic acid, (Z)-3-(1H-Imidazol-5-yl)acrylic acid, (E)-Urocanic acidCas No. 7699-35-6
cis-Urocanic acid ((E)-Urocanic acid) is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
Pack SizePriceAvailabilityQuantity
1 mg$219In Stock
5 mg$463In Stock
10 mg$683In Stock
25 mg$1,070In Stock
50 mg$1,450In Stock
100 mg$1,950In Stock
500 mg$3,890In Stock
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Purity:99.78%
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Product Introduction

Bioactivity
Description
cis-Urocanic acid ((E)-Urocanic acid) is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
In vitro
Treatment with 100 μg/mL cis-Urocanic acid completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation, with no significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability in non-irradiated cells in both cell types [1].
Aliascis-UCA, (Z)-Urocanic acid, (Z)-Imidazole-4-acrylic acid, (Z)-3-(1H-Imidazol-5-yl)acrylic acid, (E)-Urocanic acid
Chemical Properties
Molecular Weight138.12
FormulaC6H6N2O2
Cas No.7699-35-6
SmilesOC(=O)\C=C/c1cnc[nH]1
Relative Density.1.430 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 40 mg/mL (289.6 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM7.2401 mL36.2004 mL72.4008 mL362.0041 mL
5 mM1.4480 mL7.2401 mL14.4802 mL72.4008 mL
10 mM0.7240 mL3.6200 mL7.2401 mL36.2004 mL
20 mM0.3620 mL1.8100 mL3.6200 mL18.1002 mL
50 mM0.1448 mL0.7240 mL1.4480 mL7.2401 mL
100 mM0.0724 mL0.3620 mL0.7240 mL3.6200 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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