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Voreloxin

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Catalog No. T6724Cas No. 175414-77-4
Alias Vosaroxin, SNS-595, AG 7352

Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.

Voreloxin

Voreloxin

😃Good
Catalog No. T6724Alias Vosaroxin, SNS-595, AG 7352Cas No. 175414-77-4
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Pack SizePriceAvailabilityQuantity
1 mg116 €35 days
5 mg370 €35 days
25 mg1.406 €35 days
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Product Introduction

Bioactivity
Description
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
In vitro
Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4]
AliasVosaroxin, SNS-595, AG 7352
Chemical Properties
Molecular Weight401.44
FormulaC18H19N5O4S
Cas No.175414-77-4
Relative Density.1.52 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (49.82 mM), Heating is recommended.
H2O: <1 mg/mL
Ethanol: <1 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4910 mL12.4552 mL24.9103 mL124.5516 mL
5 mM0.4982 mL2.4910 mL4.9821 mL24.9103 mL
10 mM0.2491 mL1.2455 mL2.4910 mL12.4552 mL
20 mM0.1246 mL0.6228 mL1.2455 mL6.2276 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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