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VU6005649

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COA HNMR HPLC

VU6005649

Catalog No. T13321Cas No. 2137047-43-7

VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).

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Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$56	In Stock
10 mg	$89	In Stock
25 mg	$179	In Stock
50 mg	$289	In Stock
100 mg	$455	In Stock
500 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Product Introduction

Bioactivity

Description	VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
In vitro	VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor(EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50.
In vivo	In wild-type mice VU6005649 shows modest but significant pro-cognitive effects on associative learning and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model.

Chemical Properties

Molecular Weight	357.28
Formula	C16H12F5N3O
Cas No.	2137047-43-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (167.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7989 mL	13.9946 mL	27.9893 mL	139.9463 mL
5 mM	0.5598 mL	2.7989 mL	5.5979 mL	27.9893 mL
10 mM	0.2799 mL	1.3995 mL	2.7989 mL	13.9946 mL
20 mM	0.1399 mL	0.6997 mL	1.3995 mL	6.9973 mL
50 mM	0.0560 mL	0.2799 mL	0.5598 mL	2.7989 mL
100 mM	0.0280 mL	0.1399 mL	0.2799 mL	1.3995 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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