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Xestospongin C
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Catalog No. T23538Cas No. 88903-69-9
Alias (-)-Xestospongin C
Xestospongin C ((-)-Xestospongin C) is a selective inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor and also inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). It has neuroprotective effects in APP/PS1 AD mice, improving cognitive and pathological deficits associated with Alzheimer's disease.
Xestospongin C
😃Good
Catalog No. T23538Alias (-)-Xestospongin CCas No. 88903-69-9
Xestospongin C ((-)-Xestospongin C) is a selective inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor and also inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). It has neuroprotective effects in APP/PS1 AD mice, improving cognitive and pathological deficits associated with Alzheimer's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 μg | $289 | 35 days | |
| 50 μg | $1,178 | 35 days | |
| 100 μg | $2,098 | 35 days | |
| 250 μg | $4,668 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Xestospongin C ((-)-Xestospongin C) is a selective inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor and also inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). It has neuroprotective effects in APP/PS1 AD mice, improving cognitive and pathological deficits associated with Alzheimer's disease. |
| In vitro | Xestospongin C (3-10 μM) attenuated antigen-induced increase in cytoplasmic calcium levels and degranulation in RBL-2H3 mast cells. [1] Xestospongin C (3 μM) attenuates the positive inotropic effect of alpha-adrenergic stimulation in guinea pig muscles. [3] |
| In vivo | Xestospongin C (3μmol, injected into the brain) significantly improved the cognitive behavior and pathological status of APP/PS1-AD mice. [2] |
| Alias | (-)-Xestospongin C |
| Molecular Weight | 446.71 |
| Formula | C28H50N2O2 |
| Cas No. | 88903-69-9 |
| Smiles | [C@@]12([N@@]3CC[C@](O1)(CCCCCC[C@]4([C@@]5(O[C@](CCCCCC[C@]2(CCC3)[H])(CC[N@]5CCC4)[H])[H])[H])[H])[H] |
| Relative Density. | 1.05 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 2 mg/mL (4.48 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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