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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
2 mg | $122 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $313 | In Stock | |
25 mg | $528 | In Stock | |
50 mg | $763 | In Stock | |
100 mg | $1,070 | In Stock | |
500 mg | $2,130 | In Stock | |
1 mL x 10 mM (in DMSO) | $218 | In Stock |
Description | YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1]. |
In vitro | YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) has antiproliferative activity with an IC 50 value of 5.33 nM in NCI-H226 cells [1]. |
In vivo | YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) exhibits anti-tumor activity without significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model) [1]. |
Molecular Weight | 390.33 |
Formula | C19H14F4N4O |
Cas No. | 2762617-31-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (230.6 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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