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YTX-465

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COA HNMR

YTX-465

Catalog No. T9722Cas No. 2225824-53-1

YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).

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Pack Size	Price	Availability
1 mg	$293	In Stock
5 mg	$622	In Stock
10 mg	$983	In Stock
25 mg	$1,460	In Stock
50 mg	$1,970	In Stock
100 mg	$2,650	In Stock
1 mL x 10 mM (in DMSO)	$713	In Stock

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Product Introduction

Bioactivity

Description

YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).

In vitro

YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465[1]. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465[1].

Chemical Properties

Molecular Weight	458.51
Formula	C25H26N6O3
Cas No.	2225824-53-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (109.05 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1810 mL	10.9049 mL	21.8098 mL	109.0489 mL
5 mM	0.4362 mL	2.1810 mL	4.3620 mL	21.8098 mL
10 mM	0.2181 mL	1.0905 mL	2.1810 mL	10.9049 mL
20 mM	0.1090 mL	0.5452 mL	1.0905 mL	5.4524 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1810 mL
100 mM	0.0218 mL	0.1090 mL	0.2181 mL	1.0905 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc