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Zardaverine
🥰Excellent
Catalog No. T17284Cas No. 101975-10-4
Alias BY 290, B 84290
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction.
Zardaverine
🥰Excellent
Purity: 99.11%
Catalog No. T17284Alias BY 290, B 84290Cas No. 101975-10-4
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $99 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Purity:99.11%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction. |
| In vitro | Zardaverine selectively inhibits the growth of human hepatocellular carcinoma (HCC) cells in vitro when administered at concentrations ranging from 0 to 30 µM for 72 hours[3].Selective antitumor activity of Zardaverine is observed, closely related to the regulation of cell cycle-associated proteins, but independent of PDE3/4 inhibition[3].At a concentration of 0.1 µM for 24 hours, Zardaverine selectively induces G0/G1-phase arrest and dysregulates cell cycle-associated proteins in HCC cells[3].Zardaverine induces apoptosis in a time- and concentration-dependent manner in Bel-7402 and SMMC-7721 cells. The concentrations used include 0.01, 0.03, 0.1, 0.3, and 1 µM over 48 hours, as well as 0.3 and 1 µM over 24, 36, 48, 60, and 72 hours[3]. |
| Alias | BY 290, B 84290 |
| Molecular Weight | 268.22 |
| Formula | C12H10F2N2O3 |
| Cas No. | 101975-10-4 |
| Smiles | COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1 |
| Relative Density. | 1.38g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (74.57 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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