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ZIM
ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research.
Catalog No. T72024Cas No. 301298-87-3
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Purity:99.13%
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ZIM
Catalog No. T72024Cas No. 301298-87-3
ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $55 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $178 | In Stock | |
| 50 mg | $296 | In Stock | |
| 100 mg | $476 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research. |
| In vivo | ZIM (i.p., 12, 24, and 48 mg/kg) significantly reduces chromosomal micronucleus frequency at all doses in adult male Swiss mice, exhibiting a chemopreventive effect within 24 to 72 hours, and achieving damage reduction between 38.36% and 83.26%.[1] Additionally, ZIM at these concentrations lowers liver and kidney cell death induced by cisplatin-CIS and doxorubicin-DOX, with a decrease in liver damage in the CIS group of 79.27%, 75.20%, and 52.84%, respectively, and 62.06%, 59.44%, and 77.80% in the DOX group. The reduction in kidney damage in the CIS group is 45.29%, 36.09%, and 41.61%, respectively, and in the DOX group, it is 28.00%, 21.41%, and 30.82%.[1] |
| Molecular Weight | 349.38 |
| Formula | C20H19N3O3 |
| Cas No. | 301298-87-3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (28.62 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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