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0990CL
🥰Excellent
Catalog No. T13983Cas No. 511514-03-7
0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL could partially restore cAMP level, and high concentration of 0990CL (10μM) began to have negative effects on cell viability.
0990CL
🥰Excellent
Purity: 98.86%
Catalog No. T13983Cas No. 511514-03-7
0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL could partially restore cAMP level, and high concentration of 0990CL (10μM) began to have negative effects on cell viability.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 202 € | In Stock | |
| 5 mg | 511 € | In Stock | |
| 10 mg | 739 € | In Stock | |
| 25 mg | 1.121 € | In Stock | |
| 50 mg | 1.539 € | In Stock | |
| 100 mg | 2.071 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 534 € | In Stock |
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Purity:98.86%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL could partially restore cAMP level, and high concentration of 0990CL (10μM) began to have negative effects on cell viability. |
| In vitro | 0990CL (at a concentration of 30 μM with a 30-minute pre-treatment) exhibits preferential binding to Gαi1 compared to Gαq. It displays selectivity towards Gαi and Gαq, resulting in a maximum reduction of endpoint fluorescence by 38±8% and 10%, respectively. Treatment with 0990CL (100 nM to 1 μM , 24 h) restores α2AR/Gαi-mediated cAMP levels induced by Fsk and UK14304 in HEK293 GloSensor cells. At a dosage of 100 nM, it reinstates 31% of the reduced cAMP levels[1]. |
| Molecular Weight | 343.42 |
| Formula | C21H21N5 |
| Cas No. | 511514-03-7 |
| Smiles | N(C=1N=C(C2=C(N1)C=CC=C2)C3=CC=CC=C3)C=4NC(C)(C)C=C(C)N4 |
| Relative Density. | 1.21 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45.0 mg/mL (131.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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