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HJC0350
🥰Excellent
Catalog No. T6536Cas No. 885434-70-8
HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
HJC0350
🥰Excellent
Purity: 99.53%
Catalog No. T6536Cas No. 885434-70-8
HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 28 € | In Stock | |
| 10 mg | 36 € | In Stock | |
| 25 mg | 78 € | In Stock | |
| 50 mg | 130 € | In Stock | |
| 100 mg | 224 € | In Stock | |
| 200 mg | 333 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 29 € | In Stock |
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Purity:99.53%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1. |
| Targets&IC50 | EPAC2:0.3 μM |
| In vitro | HJC0350 selectively blocks cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation. In HEK293/EPAC2-FL cells, HJC0350 also inhibits 007-AM mediated cellular activation of EPAC2. [1] |
| Kinase Assay | In Vitro IRE1 RNase and RIDD Assays: Analysis of radiolabeled Xbp1 substrate cleavage is performed as previously except that mammalian IRE1 reaction buffer is used. In vitro RIDD substrates are synthesized by in vitro transcription using the T7-MAXIscript Kit in the presence of 32P ATP or Cy5-UTP on templates isolated by RT-PCR from mouse Min6 cells (Ins2) or PCR from cloned XBP1 cDNA. The resulting products are gel purified to obtain full-length substrate. Reactions are then separated by 15% UREA-PAGE for analysis by phosphorimaging or by near-infrared imaging using the LI-COR Odyssey scanner. |
| Molecular Weight | 277.38 |
| Formula | C15H19NO2S |
| Cas No. | 885434-70-8 |
| Smiles | Cc1cc(C)n(c1)S(=O)(=O)c1c(C)cc(C)cc1C |
| Relative Density. | 1.13 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (60.09 mM), Sonication is recommended.  Ethanol: 5.6 mg/mL (20 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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