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ESI-05
🥰Excellent
Catalog No. T15247Cas No. 5184-64-5
Alias NSC 116966
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.
ESI-05
🥰Excellent
Purity: 98.00%
Catalog No. T15247Alias NSC 116966Cas No. 5184-64-5
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $33 | In Stock | |
| 5 mg | $52 | In Stock | |
| 10 mg | $94 | In Stock | |
| 25 mg | $169 | In Stock | |
| 50 mg | $285 | In Stock | |
| 100 mg | $487 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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ESI-09
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CitedSelect Batch
Purity:98.00%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. |
| Targets&IC50 | EPAC2:0.4 μM |
| Alias | NSC 116966 |
| Molecular Weight | 274.38 |
| Formula | C16H18O2S |
| Cas No. | 5184-64-5 |
| Smiles | Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C |
| Relative Density. | 1.129 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 83.33 mg/mL (303.70 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Diacylglycerol acyltransferasediabetesInhibitorinhibitIntracranial hemorrhage (ICH)AcyltransferasecAMPacyl-CoA:cholesterol acyltransferaseinsulin secretionmono- acylglycerol acyltransferaseNSC-116966exchange proteins directly activated by cAMP 2 (EPAC2)neurological disordersNSC116966ESI-05ESI 05ESI05GEFDiglyceride acyltransferase
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