Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 185.00 | |
50 mg | In stock | $ 276.00 | |
100 mg | In stock | $ 397.00 |
Description | 1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction. |
Source |
Synonyms | Praeruptorin A, (-)-Praeruptorin A |
Molecular Weight | 386.4 |
Formula | C21H22O7 |
CAS No. | 73069-25-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 70 mg/mL(181.2 mM)
Ethanol: Soluble
Pyridine, Methanol, etc.: Soluble
You can also refer to dose conversion for different animals. More
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(±)-Praeruptorin A 73069-25-7 Cytoskeletal Signaling MAPK Membrane transporter/Ion channel Metabolism PI3K/Akt/mTOR signaling Akt Calcium Channel p38 MAPK Ca channels Ca2+ channels inhibit Praeruptorin A Inhibitor (±)Praeruptorin A (±) Praeruptorin A (-)-Praeruptorin A inhibitor