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12-HETE
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Catalog No. T35507Cas No. 71030-37-0
Alias (±)12-HETE
12-HETE ((±)12-HETE) is a modulator of PGE2, with both anti-thrombotic and pro-thrombotic effects, inducing PGE2 release and COX-2 expression via phospholipase A2 (sPLA2-IIA) inducers. It is also a neuroregulator activating retinal cell endothelial dysfunction in diabetic retinopathy.
12-HETE
😃Good
Catalog No. T35507Alias (±)12-HETECas No. 71030-37-0
12-HETE ((±)12-HETE) is a modulator of PGE2, with both anti-thrombotic and pro-thrombotic effects, inducing PGE2 release and COX-2 expression via phospholipase A2 (sPLA2-IIA) inducers. It is also a neuroregulator activating retinal cell endothelial dysfunction in diabetic retinopathy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $180 | 35 days | |
| 50 μg | $338 | 35 days | |
| 100 μg | $638 | 35 days | |
| 250 μg | $1,410 | 35 days |
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Concentration:0.1 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | 12-HETE ((±)12-HETE) is a modulator of PGE2, with both anti-thrombotic and pro-thrombotic effects, inducing PGE2 release and COX-2 expression via phospholipase A2 (sPLA2-IIA) inducers. It is also a neuroregulator activating retinal cell endothelial dysfunction in diabetic retinopathy. |
| In vitro | 12-HETE (0.1 μM) activates Muller cells (MCs), enhances glutamate production, and induces inflammation and oxidation. [1] 1 μM exogenous 12-HETE significantly reduced SD-induced cell viability. 12-HETE inhibited SD-induced caspase-3 activity in a concentration-dependent manner with IC50 of 1.13 μM. In OVCAR-3 cells, treatment with 1 μM 12-HETE resulted in increased ILK expression. 1 μM 12-HETE induced the expression of Bcl-2, an anti-apoptotic protein, and inhibited the expression of Bax, a pro-apoptotic protein, and these effects were attenuated by ILK siRNA. [2] |
| Alias | (±)12-HETE |
| Molecular Weight | 320.47 |
| Formula | C20H32O3 |
| Cas No. | 71030-37-0 |
| Smiles | C(\C(C/C=C\CCCCC)O)=C/C=C\C/C=C\CCCC(O)=O |
| Relative Density. | 0.984 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: Miscible DMF: Miscible 0.1 M Na2CO3: 2.00 mg/mL (6.24 mM) PBS (pH 7.2): 0.80 mg/mL (2.50 mM) Ethanol: Miscible | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
PBS (pH 7.2)/0.1 M Na2CO3
0.1 M Na2CO3
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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