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(E)-[6]-Dehydroparadol

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Purity:99.87%

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COA HPLC HNMR

(E)-[6]-Dehydroparadol

Catalog No. T13436Cas No. 878006-06-5

(E)-[6]-Dehydroparadol ((6)-Dehydroparadol), an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.

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Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$85	In Stock
10 mg	$118	In Stock
25 mg	$218	In Stock
50 mg	$297	In Stock
100 mg	$428	In Stock
500 mg	$968	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock

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Product Introduction

Bioactivity

Description	(E)-[6]-Dehydroparadol ((6)-Dehydroparadol), an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.
In vitro	(E)-[6]-Dehydroparadol (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 µM, respectively. (E)-[6]-Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells[1].
In vivo	(E)-[6]-Dehydroparadol at a concentration of 5 µM for 24 hours increases the fluorescence signal of Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] in Tg(gstp1:GFP) transgenic zebrafish embryos.
Alias	(6)-Dehydroparadol

Chemical Properties

Molecular Weight	276.37
Formula	C17H24O3
Cas No.	878006-06-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (434.2 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6183 mL	18.0917 mL	36.1834 mL	180.9169 mL
5 mM	0.7237 mL	3.6183 mL	7.2367 mL	36.1834 mL
10 mM	0.3618 mL	1.8092 mL	3.6183 mL	18.0917 mL
20 mM	0.1809 mL	0.9046 mL	1.8092 mL	9.0458 mL
50 mM	0.0724 mL	0.3618 mL	0.7237 mL	3.6183 mL
100 mM	0.0362 mL	0.1809 mL	0.3618 mL	1.8092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc